5 SIMPLE STATEMENTS ABOUT METHADONE J CODE EXPLAINED

[61] Like a lot of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with diverse potency. Dextromethadone, that is less strong being an opioid, is much more potent at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone contains a lower affinity, with an IC50 of ~2